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Article

Calmodulin binds to Drosophila TRP with an unexpected mode.

Structure (London, England : 1993) - 1 Apr 2021

Chen Weidi, Shen Zeyu, Asteriti Sabrina, Chen Zijing, Ye Fei, Sun Ziling, Wan Jun, Montell Craig, Hardie Roger C, Liu Wei, Zhang Mingjie

Abstract excerpt

Drosophila TRP is a calcium-permeable cation channel essential for fly visual signal transduction. During phototransduction, Ca2+ mediates both positive and negative feedback regulation on TRP channel activity, possibly via binding to calmodulin (CaM). However, the molecular mechanism underlying Ca2+ modulated CaM/TRP interaction is poorly understood. Here, we discover an unexpected, Ca2+-dependent binding mode...

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Identifiers

PMID: 33326749
DOI: 10.1016/j.str.2020.11.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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