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Article

Calcium binding to calmodulin mutants having domain-specific effects on the regulation of ion channels.

Biochemistry - 5 Dec 2006

VanScyoc Wendy S, Newman Rhonda A, Sorensen Brenda R, Shea Madeline A

Abstract excerpt

Calmodulin (CaM) is an essential, eukaryotic protein comprised of two highly homologous domains (N and C). CaM binds four calcium ions cooperatively, regulating a wide array of target proteins. A genetic screen of Paramecia by Kung [Kung, C. et al. (1992) Cell Calcium 13, 413-425] demonstrated that the domains of CaM have separable physiological roles: "under-reactive" mutations affecting calcium-dependent sodium...

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Identifiers

PMID: 17128970
DOI: 10.1021/bi061134d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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