Calcium binding site mutants of calmodulin adopt abnormal conformations in complexes with model target peptides.

Article

Calcium binding site mutants of calmodulin adopt abnormal conformations in complexes with model target peptides.

Biochemistry and molecular biology international - 1 Mar 1993

Mukherjea P, Beckingham K

Abstract excerpt

We have examined the ability of two series of calcium binding site mutants of Drosophila calmodulin to form complexes with the model target peptides melittin and mastoparan. Unlike the wild-type complex, the 1:1 protein:melittin complexes formed by mutants of the C-terminal sites are unable to bi...

Topics

Binding Sites
Calcium
Calmodulin
Electrophoresis, Polyacrylamide Gel
Glycerol
Intercellular Signaling Peptides and Proteins
Melitten
Mutation
Peptides
Protein Conformation
Wasp Venoms

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