Calcium binding site mutants of calmodulin adopt abnormal conformations in complexes with model target peptides.

Abstract excerpt

We have examined the ability of two series of calcium binding site mutants of Drosophila calmodulin to form complexes with the model target peptides melittin and mastoparan. Unlike the wild-type complex, the 1:1 protein:melittin complexes formed by mutants of the C-terminal sites are unable to bind a second molecule of melittin. In contrast, a site 2 mutant shows increased ability to bind two molecules of...

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