Article
Confirmation of susceptibility locus on chromosome 13 in Australian breast cancer families.
Human genetics - 1 Jul 1996
Grimmond S M, Palmer J M, Walters M K, Scott C, Nancarrow D J, Teh B T, Elmes C, Pyke C, Khoo S K, Bennett I, Wetzig N, Hayward N K
Abstract excerpt
Two major genes determining predisposition to breast cancer, termed BRCA1 and BRCA2, have been mapped to the long arms of chromosomes 17 and 13, respectively. Each locus is believed to account for approximately 40% of cases of familial breast cancer. We used linkage and haplotype analysis with simple tandem repeat polymorphisms at chromosomal bands 17q21 and 13q12 to determine the contribution of the BRCA1 and...
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