Article
Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential.
The EMBO journal - 1 Dec 1993
Shimazaki T, Okazawa H, Fujii H, Ikeda M, Tamai K, McKay R D, Muramatsu M, Hamada H
Abstract excerpt
The Oct-3 gene is expressed in highly undifferentiated cells and is implicated in mammalian early embryogenesis. We have generated a series of hybrid cells between pluripotent embryonal carcinoma cells (Oct-3+) and fibroblasts (Oct-3-), and have studied the regulation and function of Oct-3. Upon...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Cell Differentiation
- DNA
- DNA-Binding Proteins
- Embryonal Carcinoma Stem Cells
- Hybrid Cells
- L Cells
- Mice
- Molecular Sequence Data
- Neoplastic Stem Cells
- Octamer Transcription Factor-3
- Phenotype
- Transcription Factors
- Transcriptional Activation