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Article

Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential.

The EMBO journal - 1 Dec 1993

Shimazaki T, Okazawa H, Fujii H, Ikeda M, Tamai K, McKay R D, Muramatsu M, Hamada H

Abstract excerpt

The Oct-3 gene is expressed in highly undifferentiated cells and is implicated in mammalian early embryogenesis. We have generated a series of hybrid cells between pluripotent embryonal carcinoma cells (Oct-3+) and fibroblasts (Oct-3-), and have studied the regulation and function of Oct-3. Upon fusion, the hybrid cells differentiated to nestin+/Brn-2+ cells resembling neuroepithelial stem cells. Expression of...

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Identifiers

PMID: 8223459
DOI: 10.1002/j.1460-2075.1993.tb06138.x
PMCID: PMC413873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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