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Article

Structural Requirements for the Complement Regulatory Activities of C4BP

1 Jul 2001

Abstract excerpt

C4b-binding protein (C4BP) is a regulator of the classical complement pathway C3 convertase (C4bC2a complex). It is a disulfide-linked polymer of seven alpha-chains and a unique beta-chain; the alpha- and beta-chains are composed of eight and three complement control protein (CCP) domains, respectively. To elucidate the importance of the polymeric nature of C4BP and the structural requirements for the interaction...

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Identifiers

PMID: 11369776
DOI: 10.1074/jbc.m102445200

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