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Article

Mechanistic insights into complement pathway inhibition by CR1 domain duplication

5 Jun 2024

Abstract excerpt

Complement receptor 1 (CR1) is a membrane glycoprotein with a highly duplicated domain structure able to bind multiple ligands such as C3b and C4b, the activated fragments of complement components C3 and C4, respectively. We have previously used our knowledge of this domain structure to identify CSL040, a soluble extracellular fragment of CR1 containing the long homologous repeat (LHR) domains A, B, and C. CSL040...

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PMID: 38844131
DOI: 10.1016/j.jbc.2024.107451

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