Article
The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway.
Virology - 1 Sept 1994
Hung S L, Peng C, Kostavasili I, Friedman H M, Lambris J D, Eisenberg R J, Cohen G H
Abstract excerpt
Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) binds the human complement fragment C3b, but the two proteins differ in their ability to bind C3b on infected cell surfaces. In addition, gC-1, but not gC-2, accelerates the decay of the alternative pathway C3 convertase, thereby affecting later steps of the complement cascade. Previously, we constructed linker insertion and deletion...
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