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Article

Modified entry and syncytium formation by herpes simplex virus type 1 mutants selected for resistance to heparin inhibition.

Virology - 1 Dec 1996

Pertel P E, Spear P G

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) mutants were selected by passage of HSV-1 (KOS) in HEp-2 cells such that binding and penetration occurred in the presence of heparin. Analysis of selected uncloned virus pools revealed that approximately 95% of virus formed syncytia and greater than 58% were gC-negative. Plaque-purified gC-negative syncytial mutants were more resistant than HSV-1 (KOS) to heparin inhibition, as...

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PMID: 8941319
DOI: 10.1006/viro.1996.0624

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