Article
Immune evasion by herpes simplex virus type 1, strategies for virus survival.
Transactions of the American Clinical and Climatological Association - 1 Jan 2003
Friedman Harvey M
Abstract excerpt
Many viruses capable of persistent or recurrent infections have evolved strategies to evade host immunity. Viral evasion molecules target components of innate and acquired immunity, including complement proteins, natural killer cells, MHC Class I or Class II molecules and antibody. Our work focuses on HSV-1 glycoproteins gC and gE that impair antibody and complement responses. gC inhibits complement activation by...
Topics
- Animals
- Antibodies, Viral
- Female
- Herpes Simplex
- Herpesvirus 1, Human
- Herpesvirus Vaccines
- Immunization, Passive
- Mice
- Mice, Inbred BALB C
- Mutation
- Neutralization Tests
- Viral Envelope Proteins
- Virulence