Article
Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo.
Journal of virology - 1 Oct 1998
Lubinski J M, Wang L, Soulika A M, Burger R, Wetsel R A, Colten H, Cohen G H, Eisenberg R J, Lambris J D, Friedman H M
Abstract excerpt
Many microorganisms encode proteins that interact with molecules involved in host immunity; however, few of these molecules have been proven to promote immune evasion in vivo. Herpes simplex virus type 1 (HSV-1) glycoprotein C (gC) binds complement component C3 and inhibits complement-mediated virus neutralization and lysis of infected cells in vitro. To investigate the importance of the interaction between gC...
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