Article
Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease.
Clinical science (London, England : 1979) - 1 Sept 1998
Malik N M, Syrris P, Schwartzman R, Kaski J C, Crossman D C, Francis S E, Carter N D, Jeffery S
Abstract excerpt
1. Many studies have shown that hyperhomocysteinaemia is a risk factor for atherosclerotic vascular disease. A mutation (C-677T) in the gene coding for the methylenetetrahydrofolate reductase (MTHFR) enzyme has been shown to produce a thermolabile form of the enzyme. Homozygosity for this mutatio...
Topics
- Aged
- Case-Control Studies
- Coronary Angiography
- Coronary Disease
- Genetic Predisposition to Disease
- Homozygote
- Humans
- London
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Oxidoreductases Acting on CH-NH Group Donors
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Restriction Mapping
- Risk Factors