Thyroid hormone receptor beta is essential for development of auditory function.

doi:10.1038/ng0796-354

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Article

Thyroid hormone receptor beta is essential for development of auditory function.

Nature genetics - 1 Jul 1996

Forrest D, Erway L C, Ng L, Altschuler R, Curran T

Abstract excerpt

Congenital thyroid disorders are often associated with profound deafness, indicating a requirement for thyroid hormone (T3) and its receptors in the development of hearing. Two T3 receptor genes, Tr alpha and Tr beta are differentially expressed, although in overlapping patterns, during developme...

Topics

Animals
Auditory Threshold
Base Sequence
Cochlea
Deafness
Evoked Potentials, Auditory, Brain Stem
Female
Gene Expression Regulation, Developmental
Homozygote
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Mutant Strains
Molecular Sequence Data
Mutation
Phenotype
Receptors, Thyroid Hormone

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Open in PubMed

Identifiers

PMID: 8673137
DOI: 10.1038/ng0796-354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8673137-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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