Article
Thyroid hormone receptor beta is essential for development of auditory function.
Nature genetics - 1 Jul 1996
Forrest D, Erway L C, Ng L, Altschuler R, Curran T
Abstract excerpt
Congenital thyroid disorders are often associated with profound deafness, indicating a requirement for thyroid hormone (T3) and its receptors in the development of hearing. Two T3 receptor genes, Tr alpha and Tr beta are differentially expressed, although in overlapping patterns, during development. Thus, the extent to which they mediate unique or redundant functions is unclear. We demonstrate that Tr...
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