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Article

Knock-in mouse model for resistance to thyroid hormone (RTH): an RTH mutation in the thyroid hormone receptor beta gene disrupts cochlear morphogenesis.

Journal of the Association for Research in Otolaryngology : JARO - 1 Sept 2002

Griffith Andrew J, Szymko Yvonne M, Kaneshige Masahiro, Quiñónez Rafael E, Kaneshige Kumiko, Heintz Kasey A, Mastroianni Mary Ann, Kelley Matthew W, Cheng Sheue-yann

Abstract excerpt

Thyroid hormone and the beta isoform of its receptor, Trb, are essential for normal development of the mammalian auditory system. We have analyzed auditory system function and structure in a mouse strain with a targeted Thrb mutation, Thrb(PV), which leads to the loss of binding of thyroid hormone (T3) to the Trb protein. Heterozygosity for the orthologous human THRB(PV) mutation and other similar mutations in...

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Identifiers

PMID: 12382103
DOI: 10.1007/s101620010092
PMCID: PMC3202409

Genes

THRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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