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Article

Deafness in TRbeta mutants is caused by malformation of the tectorial membrane.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Feb 2009

Winter Harald, Rüttiger Lukas, Müller Marcus, Kuhn Stephanie, Brandt Niels, Zimmermann Ulrike, Hirt Bernhard, Bress Andreas, Sausbier Matthias, Conscience Aude, Flamant Frederic, Tian Yong, Zuo Jian, Pfister Markus, Ruth Peter, Löwenheim Hubert, Samarut Jacques, Engel Jutta, Knipper Marlies

Abstract excerpt

Thyroid hormone receptor beta (TRbeta) dysfunction leads to deafness in humans and mice. Deafness in TRbeta(-/-) mutant mice has been attributed to TRbeta-mediated control of voltage- and Ca(2+)-activated K(+) (BK) channel expression in inner hair cells (IHCs). However, normal hearing in young constitutive BKalpha(-/-) mutants contradicts this hypothesis. Here, we show that mice with hair cell-specific deletion...

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Source

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Identifiers

PMID: 19244534
DOI: 10.1523/JNEUROSCI.3557-08.2009
PMCID: PMC2748340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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