Article
A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START.
The EMBO journal - 17 Jun 1996
Marini N J, Meldrum E, Buehrer B, Hubberstey A V, Stone D E, Traynor-Kaplan A, Reed S I
Abstract excerpt
In an effort to study further the mechanism of Cdc28 function and cell cycle commitment, we describe here a genetic approach to identify components of pathways downstream of the Cdc28 kinase at START by screening for mutations that decrease the effectiveness of signaling by Cdc28. The first locus to be characterized in detail using this approach was PKC1 which encodes a homolog of the Ca(2+)-dependent isozymes of...
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