Article
Phorbol ester activation of functional rat protein kinase C beta-1 causes phenotype in yeast.
Journal of cellular biochemistry - 1 Jul 1993
Riedel H, Hansen H, Parissenti A M, Su L, Shieh H L, Zhu J
Abstract excerpt
The phorbol ester receptor protein kinase C (PKC) gene family encodes essential mediators of various eukaryotic cellular signals. The molecular dissection of its mechanisms of action has been limited in part by the genetic inaccessibility and complexity of signaling in mammalian cells. Here we present a novel approach to study rat PKC beta-1 action in yeast, a simple lower eukaryotic genetic model. Expression of...
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