Article
Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae.
Cellular & molecular biology research - 1 Jan 1994
Levin D E, Bowers B, Chen C Y, Kamada Y, Watanabe M
Abstract excerpt
The PKC1 gene of the budding yeast Saccharomyces cerevisiae encodes a homolog of the alpha, beta, and gamma isoforms of mammalian PKC that is essential for cell growth. Loss of PKC1 function results in a cell lysis defect that is suppressed by osmotic stabilizing agents, suggesting a defect in cell wall integrity. In this study, we show that Pkc1p-depleted cells develop holes in their cell walls positioned at...
Topics
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Division
- Cell Wall
- Genes, Fungal
- Microscopy, Electron
- Models, Biological
- Mutation
- Phosphorylation
- Protein Kinase C
- Saccharomyces cerevisiae
- Signal Transduction