Article
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.
The Journal of clinical endocrinology and metabolism - 1 Jun 1993
Flier J S, Moller D E, Moses A C, O'Rahilly S, Chaiken R L, Grigorescu F, Elahi D, Kahn B B, Weinreb J E, Eastman R
Abstract excerpt
We have performed clinical, physiological, in vitro biochemical and genetic studies of a patient with severe insulin resistance associated with the phenotype of "pseudoacromegaly," defined as the presence of acromegaloid features in the absence of elevated levels of GH or insulin-like growth factor-I (IGF-I). Despite marked hyperinsulinemia, insulin and IGF-I binding to circulating blood cells and cultured skin...
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