Article
Retention of p53val135 wild-type function in transgenic mice.
Laboratory investigation; a journal of technical methods and pathology - 1 Jun 1996
Schaffner D L, Chévez-Barrios P, Huang S L, Barrios R, Dickey B F, Shaker M R, Rajagopalan S, Habib G M, Lebovitz R M, Lieberman M W
Abstract excerpt
We targeted a mutant p53 gene (val135), previously shown to cause tumors in transgenic mice, to the kidney and eye using a gamma-glutamyltranspeptidase promoter. Although transgene RNA was expressed in both tissues, and mutant protein could be detected at high levels in the kidney and was appropriately localized to the nuclei of proximal tubules, no gross or microscopic lesions developed, even when mice were held...
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