Article
Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys.
The American journal of pathology - 1 Apr 1993
Schaffner D L, Barrios R, Massey C, Bañez E I, Ou C N, Rajagopalan S, Aguilar-Cordova E, Lebovitz R M, Overbeek P A, Lieberman M W
Abstract excerpt
Five families of transgenic mice were derived from one-cell-stage embryos injected with gamma GT-rasT24, a fusion gene consisting of the gamma-glutamyl transpeptidase (gamma GT) 5' flanking region containing promoter I linked to a mutated (codon 12) human H-ras oncogene. The transgene was expressed selectively in the kidneys, eyes, and brains of all families as determined by reverse transcription-polymerase chain...
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