Article
Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM.
Diabetes - 1 Jul 1996
Ohagi S, Sakaguchi H, Sanke T, Tatsuta H, Hanabusa T, Nanjo K
Abstract excerpt
Proinsulin is converted to insulin by the concerted action of two sequence-specific subtilisin-like proteases termed prohormone convertase 2 (PC2) and prohormone convertase 3 (PC3). PC3 is a type I proinsulin-processing enzyme that initiates the sequential processing of proinsulin to insulin by c...
Topics
- Animals
- Aspartic Acid Endopeptidases
- Base Sequence
- DNA Primers
- Deoxyribonuclease EcoRI
- Diabetes Mellitus, Type 2
- Exons
- Genetic Variation
- Genomic Library
- Humans
- Introns
- Japan
- Mice
- Molecular Sequence Data
- Mutation
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic