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Article

Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.

The Journal of clinical endocrinology and metabolism - 1 Sept 1994

Shimokawa K, Sakura H, Otabe S, Eto K, Kadowaki H, Hagura R, Yazaki Y, Akanuma Y, Kadowaki T

Abstract excerpt

Glucokinase plays an important role in glucose metabolism in pancreatic beta-cells and liver. Recently, several mutations responsible for noninsulin-dependent diabetes mellitus (NIDDM) have been identified within the coding regions of the glucokinase gene. We screened the promoter regions using polymerase chain reaction followed by single strand conformation polymorphisms in 240 Japanese NIDDM and 111 control...

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Identifiers

PMID: 8077376
DOI: 10.1210/jcem.79.3.8077376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.PMID 8077376Read ↗

Sequence variations of the glucokinase gene in Japanese subjects with NIDDM.Semantic proximity Read ↗

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Mutation/polymorphism scanning of glucose-6-phosphatase gene promoter in noninsulin-dependent diabetes mellitus patients.Semantic proximity Read ↗

Clinical characteristics of Japanese men with glucokinase gene beta-cell promoter variant.Semantic proximity Read ↗

Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus.Semantic proximity Read ↗

[Mutations of glucokinase gene in Japanese subjects with NIDDM].Semantic proximity Read ↗

The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).Semantic proximity Read ↗

Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.Semantic proximity Read ↗

A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men.Semantic proximity Read ↗

Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese.Semantic proximity Read ↗

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.Semantic proximity Read ↗

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