Article
Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Sept 1994
Shimokawa K, Sakura H, Otabe S, Eto K, Kadowaki H, Hagura R, Yazaki Y, Akanuma Y, Kadowaki T
Abstract excerpt
Glucokinase plays an important role in glucose metabolism in pancreatic beta-cells and liver. Recently, several mutations responsible for noninsulin-dependent diabetes mellitus (NIDDM) have been identified within the coding regions of the glucokinase gene. We screened the promoter regions using p...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Base Sequence
- Diabetes Mellitus, Type 2
- Glucokinase
- Humans
- Japan
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Promoter Regions, Genetic