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Article

Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.

Diabetologia - 1 Jun 1998

Utsunomiya N, Ohagi S, Sanke T, Tatsuta H, Hanabusa T, Nanjo K

Abstract excerpt

Insulin is synthesized in the pancreatic beta cell as a larger precursor molecule proinsulin which is converted to insulin and C-peptide by the concerted action of prohormone convertase 2 (PC2), prohormone convertase 3 (PC3) and carboxypeptidase E (CPE). One of the features of non-insulin-dependent diabetes mellitus (NIDDM) is an elevation in the proinsulin level and/or proinsulin/insulin molar ratio suggesting...

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Identifiers

PMID: 9662053
DOI: 10.1007/s001250050971

Genes

CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.PMID 9662053Read ↗

Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM.Semantic proximity Read ↗

Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.Semantic proximity Read ↗

A New Cause of Obesity Syndrome Associated with a Mutation in the Carboxypeptidase Gene Detected in Three Siblings with Obesity, Intellectual Disability and Hypogonadotropic HypogonadismSemantic proximity Read ↗

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.Semantic proximity Read ↗

Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis.Semantic proximity Read ↗

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.Semantic proximity Read ↗

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene.Semantic proximity Read ↗

Characterization of the porcine carboxypeptidase E cDNA: comparative analysis and investigation of a non-synonymous SNP.Semantic proximity Read ↗

The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.Semantic proximity Read ↗

A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function.Semantic proximity Read ↗

Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice.Semantic proximity Read ↗

Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.Semantic proximity Read ↗

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