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Article

Greater frequency of K-ras Val-12 mutation in colorectal cancer as detected with sensitive methods.

Clinical chemistry - 1 Jun 1996

Carpenter K M, Durrant L G, Morgan K, Bennett D, Hardcastle J D, Kalsheker N A

Abstract excerpt

Assays for tumor mutations need to be sufficiently sensitive that a mutation can be readily detected in a high background of wild-type sequence. We have evaluated competitive allele-specific oligonucleotide (cASO) hybridization, the amplification refractory mutation system (ARMS), and a combination of cASO with mutant-enriched polymerase chain reaction (ME-PCR) for their respective sensitivities in detecting the...

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PMID: 8665682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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