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Article

A yeast protein similar to bacterial two-component regulators.

Science (New York, N.Y.) - 22 Oct 1993

Ota I M, Varshavsky A

Abstract excerpt

Many bacterial signaling pathways involve a two-component design. In these pathways, a sensor kinase, when activated by a signal, phosphorylates its own histidine, which then serves as a phosphoryl donor to an aspartate in a response regulator protein. The Sln1 protein of the yeast Saccharomyces cerevisiae has sequence similarities to both the histidine kinase and the response regulator proteins of bacteria. A...

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PMID: 8211183
DOI: 10.1126/science.8211183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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