A yeast protein similar to bacterial two-component regulators.

doi:10.1126/science.8211183

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Article

A yeast protein similar to bacterial two-component regulators.

Science (New York, N.Y.) - 22 Oct 1993

Ota I M, Varshavsky A

Abstract excerpt

Many bacterial signaling pathways involve a two-component design. In these pathways, a sensor kinase, when activated by a signal, phosphorylates its own histidine, which then serves as a phosphoryl donor to an aspartate in a response regulator protein. The Sln1 protein of the yeast Saccharomyces cerevisiae has sequence similarities to both the histidine kinase and the response regulator proteins of bacteria. A...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Fungal Proteins
Genes, Fungal
Histidine Kinase
Intracellular Signaling Peptides and Proteins
Ligases
Molecular Sequence Data
Mutation
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Alignment

Signal Transduction

Ubiquitin-Protein Ligases

Source

Open in PubMed

Identifiers

PMID: 8211183
DOI: 10.1126/science.8211183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8211183-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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