Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment.

doi:10.1007/s004390050367

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Article

Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment.

Human genetics - 1 Mar 1997

Amaravadi R, Glerum D M, Tzagoloff A

Abstract excerpt

The COX17 gene of Saccharomyces cerevisiae codes for a cytoplasmic protein essential for the expression of functional cytochrome oxidase. This protein has been implicated in targeting copper to mitochondria. To determine if Cox17p is present in mammalian cells, a yeast strain carrying a null muta...

Topics

Amino Acid Sequence
Base Sequence
Carrier Proteins
Cation Transport Proteins
Copper
Copper Transport Proteins
DNA, Complementary
Electron Transport Complex IV
Escherichia coli
Genetic Complementation Test
HeLa Cells
Humans
Mitochondria
Molecular Chaperones
Molecular Sequence Data
Mutation
Plasmids
Proteins

Source

Open in PubMed

Identifiers

PMID: 9050918
DOI: 10.1007/s004390050367

Genes

COX17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9050918-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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