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Article

Characterization of the peroxide sensitivity of COX-deficient yeast strains reveals unexpected relationships between COX assembly proteins.

Free radical biology & medicine - 15 Oct 2011

Veniamin Simona, Sawatzky Luanne G, Banting Graham S, Glerum D Moira

Abstract excerpt

A number of distinct cuproproteins of the mitochondrial inner membrane are required for the assembly of cytochrome oxidase (COX), thought to function in a "bucket brigade" fashion to provide copper to the Cu(A) and Cu(B) sites. In yeast, the loss of two these proteins, Sco1p and Cox11p, leads to respiratory deficiency and a specific inability to survive exposure to hydrogen peroxide (H(2)O(2)). Using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21821119
DOI: 10.1016/j.freeradbiomed.2011.06.024

Genes

SCO2
COX11
SCO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Characterization of the peroxide sensitivity of COX-deficient yeast strains reveals unexpected relationships between COX assembly proteins.PMID 21821119Read ↗

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Mutagenesis reveals a specific role for Cox17p in copper transport to cytochrome oxidase.Semantic proximity Read ↗

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