Article
Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.
Molecular and cellular biology - 1 Nov 2002
Takahashi Yoshinori, Kako Koichiro, Kashiwabara Shin-Ichi, Takehara Akio, Inada Yoshiko, Arai Hidenori, Nakada Kazuto, Kodama Hiroko, Hayashi Jun-Ichi, Baba Tadashi, Munekata Eisuke
Abstract excerpt
Cox17p is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast. Although this small protein has already been cloned or purified from humans, mice, and pigs, the function of Cox17p in the mammalian system has not yet been elucidated. In vitro biochemical data for mammalian Cox17p indicate that the copper...
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