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Article

Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis.

Human molecular genetics - 15 Feb 2016

Ghosh Alok, Pratt Anthony T, Soma Shivatheja, Theriault Sarah G, Griffin Aaron T, Trivedi Prachi P, Gohil Vishal M

Abstract excerpt

Biogenesis of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain, is a complex process facilitated by several assembly factors. Pathogenic mutations were recently reported in one such assembly factor, COA6, and our previous work linked Coa6 function to mitochondrial copper metabolism and expression of Cox2, a copper-containing subunit of CcO. However, the precise role of Coa6...

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Source

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Identifiers

PMID: 26669719
DOI: 10.1093/hmg/ddv503
PMCID: PMC4743686

Genes

COA6
SCO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis.PMID 26669719Read ↗

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