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Article

Cox17 is functional when tethered to the mitochondrial inner membrane.

The Journal of biological chemistry - 13 Feb 2004

Maxfield Andrew B, Heaton Daren N, Winge Dennis R

Abstract excerpt

Cox17 is an essential protein in the assembly of cytochrome c oxidase within the mitochondrion. Cox17 is implicated in providing copper ions for formation of CuA and CuB sites in the oxidase complex. To address whether Cox17 is functional in shuttling copper ions to the mitochondrion, Cox17 was tethered to the mitochondrial inner membrane by a fusion to the transmembrane domain of the inner membrane protein,...

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Identifiers

PMID: 14615477
DOI: 10.1074/jbc.M311772200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cox17 is functional when tethered to the mitochondrial inner membrane.PMID 14615477Read ↗

Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase.Semantic proximity Read ↗

Mutagenesis reveals a specific role for Cox17p in copper transport to cytochrome oxidase.Semantic proximity Read ↗

Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment.Semantic proximity Read ↗

Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.Semantic proximity Read ↗

AtCOX17, an Arabidopsis homolog of the yeast copper chaperone COX17.Semantic proximity Read ↗

<i>Saccharomyces cerevisiae</i> Dmo2p is involved in the mitochondrial copper metabolism and is required for the stability of newly translated Cox2pSemantic proximity Read ↗

Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18.Semantic proximity Read ↗

Saccharomyces cerevisiae Dmo2p is required for the stability and maturation of newly translated Cox2p.Semantic proximity Read ↗

Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module.Semantic proximity Read ↗

Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding.Semantic proximity Read ↗

Characterization of COX19, a widely distributed gene required for expression of mitochondrial cytochrome oxidase.Semantic proximity Read ↗

COX23, a homologue of COX17, is required for cytochrome oxidase assembly.Semantic proximity Read ↗

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