Article
Differential responsiveness of a splice variant of the human type I interferon receptor to interferons.
The Journal of biological chemistry - 7 Jun 1996
Cook J R, Cleary C M, Mariano T M, Izotova L, Pestka S
Abstract excerpt
Chinese hamster ovary cells containing the yeast artificial chromosome F136C5 (alphaYAC) respond to all type I human interferons including IFN-alphaA, IFN-beta, and IFN-omega. The alphaYAC contains at least two genes encoding interferon-alpha receptor (IFN-alphaR) chains that are required for res...
Topics
- Amino Acid Sequence
- Animals
- CHO Cells
- Chromosomes, Artificial, Yeast
- Cricetinae
- DNA, Complementary
- Genetic Variation
- Histocompatibility Antigens Class I
- Humans
- Hybrid Cells
- Interferon Type I
- Molecular Sequence Data
- RNA Splicing
- Receptor, Interferon alpha-beta
- Receptors, Interferon
- Sequence Homology, Amino Acid