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Article

Recruitment of Multiple Interferon Regulatory Factors and Histone Acetyltransferase to the Transcriptionally Active Interferon A Promoters

1 Nov 2001

Abstract excerpt

Type I interferon (IFN) plays a critical role in the innate immunity against viral infection. Expression of IFNA genes in infected cells is cell type-dependent and is regulated at the transcriptional level. The present study is focused on the molecular mechanism underlying the differential expression of human IFNA1 and A2 genes. Two nucleotides, at positions -98 and -81 of IFNA1 and A2 promoter, were pivotal to...

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PMID: 11473119
DOI: 10.1074/jbc.m105121200

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