Alpha-interferon structure and natural killer cell stimulatory activity.

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Article

Alpha-interferon structure and natural killer cell stimulatory activity.

Cancer research - 1 Sept 1990

Li B L, Zhao X X, Liu X Y, Kim H S, Raska K, Ortaldo J R, Schwartz B, Pestka S

Abstract excerpt

Expression vectors for human alpha-interferon (Hu-IFN-alpha) J1, a site-specific mutant [Ser116]Hu-IFN-alpha J1, and Hu-IFN-alpha J/C or Hu-IFN-alpha C/J hybrids were constructed and expressed in Escherichia coli. These interferons and others were purified by immunoaffinity chromatography with a...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Cytotoxicity, Immunologic
Escherichia coli
Humans
Interferon Type I
Killer Cells, Natural
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Plasmids
Recombinant Proteins
Restriction Mapping
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 2201435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2201435-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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