Article
Alpha-interferon structure and natural killer cell stimulatory activity.
Cancer research - 1 Sept 1990
Li B L, Zhao X X, Liu X Y, Kim H S, Raska K, Ortaldo J R, Schwartz B, Pestka S
Abstract excerpt
Expression vectors for human alpha-interferon (Hu-IFN-alpha) J1, a site-specific mutant [Ser116]Hu-IFN-alpha J1, and Hu-IFN-alpha J/C or Hu-IFN-alpha C/J hybrids were constructed and expressed in Escherichia coli. These interferons and others were purified by immunoaffinity chromatography with a monoclonal antibody against human alpha-interferon. Their antiviral activity and ability to stimulate natural killer...
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