Article
Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells.
The Journal of biological chemistry - 4 Aug 2000
Russell-Harde D, Wagner T C, Rani M R, Vogel D, Colamonici O, Ransohoff R M, Majchrzak B, Fish E, Perez H D, Croze E
Abstract excerpt
A human cell line (U5A) lacking the type I interferon (IFN) receptor chain 2 (IFNAR2c) was used to determine the role of the IFNAR2c cytoplasmic domain in regulating IFN-dependent STAT activation, interferon-stimulated gene factor 3 (ISGF3) and c-sis-inducible factor (SIF) complex formation, gene expression, and antiproliferative effects. A panel of U5A cells expressing truncation mutants of IFNAR2c on their cell...
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