Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon-alpha hybrids.

Pharmacology & therapeutics - 1 Jun 1995

Horisberger M A, Di Marco S

Abstract excerpt

The alpha-interferons (IFN-alpha) belong to a family of polypeptides comprising several subtypes. Using recombinant DNA technology, it has been possible to create IFN hybrids that provide novel combinations of the amino acid residues from the parental protein sequences. They have been used to study structure-activity relationships of IFN-alpha and interactions with the IFN-alpha receptor, and to create analogs of...

Topics

Animals
Cattle
Computer Simulation
DNA, Recombinant
Gene Expression Regulation
Humans
Interferon-alpha
Killer Cells, Natural
Mice
Models, Structural
Mutation
Receptors, Interferon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Terminology as Topic

Source

Identifiers

PMID: 7494857
DOI: 10.1016/0163-7258(95)00008-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7494857-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon-alpha hybrids.PMID 7494857Read ↗

Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population.Semantic proximity Read ↗

Interferon at 50: new molecules, new potential, new (and old) questions.Semantic proximity Read ↗

Alpha-interferon structure and natural killer cell stimulatory activity.Semantic proximity Read ↗

Activity of hybrid type I interferons in cells lacking Tyk2: a common region of IFN-alpha 8 induces a response, but IFN-alpha2/8 hybrids can behave like IFN-beta.Semantic proximity Read ↗

Targeted mutations in IFNα2 improve its antiviral activity against various viruses.Semantic proximity Read ↗

Structure-function studies of interferon-alpha based on random mutagenesis and expression in vitro.Semantic proximity Read ↗

Creation of interferon-alpha8 mutants with amino acid substitutions against interferon-alpha receptor-2 binding sites using phage display system and evaluation of their biologic properties.Semantic proximity Read ↗

Targeted mutations in IFNα2 improve its antiviral activity against various virusesSemantic proximity Read ↗

Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-α, shows antitumor effect in vitro and in vivoSemantic proximity Read ↗

Differential responsiveness of a splice variant of the human type I interferon receptor to interferons.Semantic proximity Read ↗

Differences in Activity between α and β Type I Interferons Explored by Mutational AnalysisSemantic proximity Read ↗

Binding and activity of all human alpha interferon subtypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.