Article
Allelic losses of chromosome 10 in glioma tissues detected by quantitative single-strand conformation polymorphism analysis.
Clinical chemistry - 1 Mar 2006
Hata Nobuhiro, Yoshimoto Koji, Yokoyama Nobuhiko, Mizoguchi Masahiro, Shono Tadahisa, Guan Yanlei, Tahira Tomoko, Kukita Yoji, Higasa Koichiro, Nagata Shinji, Iwaki Toru, Sasaki Tomio, Hayashi Kenshi
Abstract excerpt
BACKGROUND: Detection of loss of heterozygosity (LOH) in clinical tissue samples is frequently difficult because samples are usually contaminated with noncancerous cells or because tumor cells in single tissues have genetic heterogeneity, and the precision of available techniques is insufficient for reliable analysis in such materials. We hypothesized that single-strand conformation polymorphism (SSCP) analysis...
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