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Article

New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme.

Genetics - 1 Dec 2005

Katic Iskra, Vallier Laura G, Greenwald Iva

Abstract excerpt

Screens for suppressors of lin-12 hypermorphic alleles in C. elegans have identified core components and modulators of the LIN-12/Notch signaling pathway. Here we describe the recovery of alleles of six new genes from a screen for suppressors of the egg-laying defect associated with elevated lin-12 activity. The molecular identification of one of the new suppressor genes revealed it as bre-5, which had previously...

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Identifiers

PMID: 16157663
DOI: 10.1534/genetics.105.048041
PMCID: PMC1389698

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Source receipt: pubmed, retrieved 7 Sept 2026.

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