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Article

Novel cancer therapy by reactivation of the p53 apoptosis pathway.

Annals of medicine - 1 Jan 2003

Bykov Vladimir J N, Wiman Klas G

Abstract excerpt

The p53 transcription factor prevents tumor development through induction of cell cycle arrest and cell death by apoptosis. As many as several hundred genes or more are regulated by p53. Around half of all human tumors carry p53 mutation, mostly point mutations that abrogate p53's specific DNA binding and transactivation activity. p53 mutation is associated with poor therapeutic response and prognosis. Tumors...

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Source

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PMID: 14649328
DOI: 10.1080/07853890310017152

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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