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Article

The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor.

European journal of biochemistry - 1 Feb 1996

Chen H C, Guan J L

Abstract excerpt

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase implicated in the signal transduction pathways initiated by integrins. However, we have previously found that platelet-derived growth factor (PDGF) could stimulate the association of FAK with phosphatidylinositol 3-kinase in NIH 3T3 cells [Chen, H.-C. & Guan, J.-L. (1994) J. Biol. Chem 269, 31229-31223], suggesting that FAK might participate in some of...

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Identifiers

PMID: 8654393
DOI: 10.1111/j.1432-1033.1996.00495.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor.PMID 8654393Read ↗

Cortactin as a target for FAK in the regulation of focal adhesion dynamics.Semantic proximity Read ↗

Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor.Semantic proximity Read ↗

Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.Semantic proximity Read ↗

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.Semantic proximity Read ↗

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex.Semantic proximity Read ↗

JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.Semantic proximity Read ↗

A-Raf associates with and regulates platelet-derived growth factor receptor signalling.Semantic proximity Read ↗

Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration.Semantic proximity Read ↗

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.Semantic proximity Read ↗

Reciprocally interacting domains of protein phosphatase 1 and focal adhesion kinase.Semantic proximity Read ↗

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.Semantic proximity Read ↗

Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor.Semantic proximity Read ↗

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