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Article

Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996

Moutouh L, Corbeil J, Richman D D

Abstract excerpt

The potential contribution of recombination to the development of HIV-1 resistance to multiple drugs was investigated. Two distinct viruses, one highly resistant to a protease inhibitor (SC-52151) and the other highly resistant to zidovudine, were used to coinfect T lymphoblastoid cells in culture. The viral genotypes could be distinguished by four mutations conferring drug resistance to each drug and by other...

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Identifiers

PMID: 8650227
DOI: 10.1073/pnas.93.12.6106
PMCID: PMC39197

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