Article
Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996
Moutouh L, Corbeil J, Richman D D
Abstract excerpt
The potential contribution of recombination to the development of HIV-1 resistance to multiple drugs was investigated. Two distinct viruses, one highly resistant to a protease inhibitor (SC-52151) and the other highly resistant to zidovudine, were used to coinfect T lymphoblastoid cells in cultur...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- HIV Protease
- HIV Protease Inhibitors
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA, Viral
- RNA-Directed DNA Polymerase
- Recombination, Genetic
- Reverse Transcriptase Inhibitors