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Article

Nucleoside and nucleotide analogs select in culture for different patterns of drug resistance in human immunodeficiency virus types 1 and 2.

Antimicrobial agents and chemotherapy - 1 Feb 2009

Ntemgwa Michel L, Toni Thomas d'Aquin, Brenner Bluma G, Oliveira Maureen, Asahchop Eugene L, Moisi Daniela, Wainberg Mark A

Abstract excerpt

Recent findings suggest bidirectional antagonisms between the K65R mutation and thymidine analogue mutations in human immunodeficiency virus type 1 (HIV-1)-infected, treatment-experienced patients, yet little is known about HIV-2 in this regard. This study addressed the effects of innate polymorphisms in HIV-2 on emergent resistance to nucleoside/nucleotide analogues. Emergent drug resistance profiles in HIV-2...

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Identifiers

PMID: 19064892
DOI: 10.1128/AAC.01109-08
PMCID: PMC2630613

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