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Article

Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance.

Journal of virology - 1 Feb 1995

Kellam P, Larder B A

Abstract excerpt

Genetic recombination between viral genomes has been shown to contribute to the generation of genetic diversity during retrovirus infections. The role of recombination in the development of human immunodeficiency virus type 1 (HIV-1) zidovudine resistance was investigated as a possible cause of the formation of the linked Leu-41/Tyr-215 resistance genotype. Zidovudine resistance is conferred by the presence of...

Topics

Amino Acid Sequence
Base Sequence
Cells, Cultured
Drug Resistance
Genetic Linkage
HIV Reverse Transcriptase
HIV-1
Humans
Molecular Sequence Data
Mutation
RNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 7529334
DOI: 10.1128/JVI.69.2.669-674.1995
PMCID: PMC188627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7529334-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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