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Article

Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana.

Molecular microbiology - 1 Jan 2009

Feng Xiuhong, Rodriguez-Contreras Dayana, Buffalo Cosmo, Bouwer H G Archie, Kruvand Elizabeth, Beverley Stephen M, Landfear Scott M

Abstract excerpt

A glucose transporter null mutant of the parasitic protozoan Leishmania mexicana, in which three linked glucose transporter genes have been deleted by targeted gene replacement, is unable to replicate as amastigote forms within phagolysomes of mammalian host macrophages and is avirulent. Spontaneous suppressors of the null mutant have been isolated that partially restore replication of parasites within...

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Identifiers

PMID: 19017272
DOI: 10.1111/j.1365-2958.2008.06531.x
PMCID: PMC2729070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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