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Article

Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability.

The EMBO journal - 16 Jul 2001

Garami A, Ilg T

Abstract excerpt

In eukaryotes, the enzyme GDP-mannose pyrophosphorylase (GDPMP) is essential for the formation of GDP-mannose, the central activated mannose donor in glycosylation reactions. Deletion of its gene is lethal in fungi, most likely as a consequence of disrupted glycoconjugate biosynthesis. Furthermore, absence of GDPMP enzyme activity and the expected loss of all mannose-containing glycoconjugates have so far not...

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Identifiers

PMID: 11447107
DOI: 10.1093/emboj/20.14.3657
PMCID: PMC125538

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Source receipt: pubmed, retrieved 7 Sept 2026.

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