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Article

Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase.

International journal for parasitology - 1 Jul 2005

Stewart James, Curtis Joan, Spurck Timothy P, Ilg Thomas, Garami Attila, Baldwin Tracey, Courret Nathalie, McFadden Geoffrey I, Davis Antony, Handman Emanuela

Abstract excerpt

In eukaryotes, the enzyme GDP-mannose pyrophosphorylase (GDP-MP) is essential for the formation of GDP-mannose, the donor of activated mannose for all glycosylation reactions. Unlike other eukaryotes, where deletion of GDP-mannose pyrophosphorylase is lethal, deletion of this gene in Leishmania mexicana has no effect on viability, but leads to the generation of avirulent parasites. In this study, we show that the...

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PMID: 15936761
DOI: 10.1016/j.ijpara.2005.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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