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Article

The Phosphodiesterase Inhibitor IBMX Blocks the Potassium Channel THIK-1 from the Extracellular Side.

Molecular pharmacology - 1 Aug 2020

Zou Xinle, Conrad Linus J, Koschinsky Kristin, Schlichthörl Günter, Preisig-Müller Regina, Netz Eugen, Krüger Jens, Daut Jürgen, Renigunta Vijay

Abstract excerpt

The two-pore domain potassium channel (K2P-channel) THIK-1 has several predicted protein kinase A (PKA) phosphorylation sites. In trying to elucidate whether THIK-1 is regulated via PKA, we expressed THIK-1 channels in a mammalian cell line (CHO cells) and used the phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (IBMX) as a pharmacological tool to induce activation of PKA. Using the whole-cell...

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PMID: 32616523
DOI: 10.1124/molpharm.120.000011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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