Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants.

Molecular pharmacology - 1 Nov 2010

Labasque Marilyne, Meffre Julie, Carrat Gaelle, Becamel Carine, Bockaert Joël, Marin Philippe

Abstract excerpt

Serotonin (5-HT)(2C) receptor is a G(q)-coupled receptor exhibiting a high degree of constitutive activity toward phospholipase C effector pathway, a process regulated by receptor mRNA editing. In addition to G protein-dependent signaling, 5-HT(2C) receptors also activate the extracellular signal-regulated kinase (ERK) 1/2 pathway independently of receptor coupling to G proteins. Constitutive activity at ERK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Arrestins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to beta-Arrestins

Share to Calmodulin

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Receptor, Serotonin, 5-HT2C

Share to RNA Editing

Source

Identifiers

PMID: 20699324
DOI: 10.1124/mol.110.066035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants.PMID 20699324Read ↗

Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.Semantic proximity Read ↗

Constitutive activity of G-protein coupled receptors: emphasis on serotonin receptors.Semantic proximity Read ↗

Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.Semantic proximity Read ↗

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.Semantic proximity Read ↗

Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses.Semantic proximity Read ↗

Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies.Semantic proximity Read ↗

Constitutive activities and inverse agonism in dopamine receptors.Semantic proximity Read ↗

The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivoSemantic proximity Read ↗

Conserved helix 7 tyrosine functions as an activation relay in the serotonin 5HT(2C) receptor.Semantic proximity Read ↗

Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms.Semantic proximity Read ↗

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.Semantic proximity Read ↗

The recombinant 5-HT1A receptor: G protein coupling and signalling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.