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Article

Neuronal phenotype dependency of agonist-induced internalization of the 5-HT(1A) serotonin receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2014

Bouaziz Elodie, Emerit Michel Boris, Vodjdani Guilan, Gautheron Vanessa, Hamon Michel, Darmon Michèle, Masson Justine

Abstract excerpt

Selective serotonin reuptake inhibitors (SSRI) are aimed at increasing brain 5-HT tone; however, this expected effect has a slow onset after starting SSRI treatment because of initial activation of 5-HT(1A) autoreceptor-mediated negative feedback of 5-HT release. After chronic SSRI treatment, 5-HT(1A) autoreceptors desensitize, which allows 5-HT tone elevation. Because 5-HT(1A) receptor (5-HT(1A)R)...

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Identifiers

PMID: 24381289
DOI: 10.1523/JNEUROSCI.0186-13.2014
PMCID: PMC6608173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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