Article
Neuronal phenotype dependency of agonist-induced internalization of the 5-HT(1A) serotonin receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2014
Bouaziz Elodie, Emerit Michel Boris, Vodjdani Guilan, Gautheron Vanessa, Hamon Michel, Darmon Michèle, Masson Justine
Abstract excerpt
Selective serotonin reuptake inhibitors (SSRI) are aimed at increasing brain 5-HT tone; however, this expected effect has a slow onset after starting SSRI treatment because of initial activation of 5-HT(1A) autoreceptor-mediated negative feedback of 5-HT release. After chronic SSRI treatment, 5-HT(1A) autoreceptors desensitize, which allows 5-HT tone elevation. Because 5-HT(1A) receptor (5-HT(1A)R)...
Topics
- Animals
- Autoreceptors
- Endocytosis
- Female
- LLC-PK1 Cells
- Neurons
- Phenotype
- Protein Binding
- Rats
- Rats, Sprague-Dawley
- Receptor, Serotonin, 5-HT1A
- Serotonin 5-HT1 Receptor Agonists
- Swine