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Article

Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2001

Baranovskaya S, Soto J L, Perucho M, Malkhosyan S R

Abstract excerpt

Genetic or epigenetic inactivation of one of the DNA mismatch repair (MMR) genes in tumor precursor cells causes a profound mutator phenotype, known as the microsatellite mutator phenotype (MMP). This mutator phenotype induces mutations not only in cancer genes that drive tumorigenesis but also in other DNA repair genes. The functional significance of these successive DNA repair gene mutations, however, has not...

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Identifiers

PMID: 11742074
DOI: 10.1073/pnas.251234498
PMCID: PMC64991

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